An oncohistone-driven H3.3K27M/CREB5/ID1 axis maintains the stemness and malignancy of diffuse intrinsic pontine glioma

Abstract Diffuse intrinsic pontine glioma (DIPG), a lethal pediatric cancer driven by H3K27M oncohistones, exhibits aberrant epigenetic regulation and stem-like cell states. Here, we uncover an axis involving H3.3K27M oncohistones, CREB5/ID1, which sustains the stem-like state of DIPG cells, promoti...

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Autores principales:	Wei Zhou, Cheng Xu, Shuangrui Yang, Haocheng Li, Changcun Pan, Zhuang Jiang, Luyang Xie, Xiaohan Li, Huimin Qiao, Da Mi, Yujie Tang, Liwei Zhang, Qiaoran Xi
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2025-04-01
Colección:	Nature Communications
Acceso en línea:	https://doi.org/10.1038/s41467-025-58795-2
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