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Targeting JAK-STAT Signalling Alters PsA Synovial Fibroblast Pro-Inflammatory and Metabolic Function

ObjectivesPsoriatic arthritis (PsA) is a chronic inflammatory disease associated with psoriasis. Janus Kinase inhibitors (JAKi) have emerged as an encouraging class of drugs for the treatment of PsA. Here, we compare the effect of four JAKi on primary PsA synovial fibroblasts (PsAFLS) activation, me...

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Furkejuvvon:
Váldodahkkit: Aisling O’Brien, Megan Mary Hanlon, Viviana Marzaioli, Siobhan C. Wade, Keelin Flynn, Ursula Fearon, Douglas J. Veale
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Frontiers Media S.A. 2021-06-01
Ráidu:Frontiers in Immunology
Fáttát:
psoriatic arthritis
metabolism
JAK-STAT (janus kinase-signal transducer and activators of transcription)
synovial fibroblast
synovial invasion
Liŋkkat:https://www.frontiersin.org/articles/10.3389/fimmu.2021.672461/full
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