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Gamma-secretase-dependent and -independent effects of presenilin1 on beta-catenin.Tcf-4 transcriptional activity.

Presenilin1 (PS1) is a component of the gamma-secretase complex mutated in cases of Familial Alzheimer's disease (FAD). PS1 is synthesized as a 50 kDa peptide subsequently processed to two 29 and 20 kDa subunits that remain associated. Processing of PS1 is inhibited by several mutations detected in...

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Principais autores: Imma Raurell, Montserrat Codina, David Casagolda, Beatriz Del Valle, Josep Baulida, Antonio García de Herreros, Mireia Duñach
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science (PLoS) 2008-01-01
סדרה:PLoS ONE
גישה מקוונת:http://europepmc.org/articles/PMC2603589?pdf=render
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