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Assessment of gastrointestinal function and enteric nervous system changes over time in the A53T mouse model of Parkinson’s disease

Abstract Gastrointestinal (GI) dysfunctions, including constipation and delayed stomach emptying, are prevalent and debilitating non-motor symptoms of Parkinson’s disease (PD). These symptoms have been associated with damage in the enteric nervous system (ENS) and the accumulation of pathogenic alph...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Myat Noe Han, Madeleine R. Di Natale, Enie Lei, John B. Furness, David I. Finkelstein, Marlene M. Hao, Shanti Diwakarla, Rachel M. McQuade
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2025-03-01
Schriftenreihe:Acta Neuropathologica Communications
Schlagworte:
Parkinson’s disease
Gastrointestinal dysfunction
Constipation
A53T
Enteric nervous system
Online-Zugang:https://doi.org/10.1186/s40478-025-01956-7
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