Community benchmarking and evaluation of human unannotated microprotein detection by mass spectrometry based proteomics

Abstract Thousands of short open reading frames (sORFs) are translated outside of annotated coding sequences. Recent studies have pioneered searching for sORF-encoded microproteins in mass spectrometry (MS)-based proteomics and peptidomics datasets. Here, we assessed literature-reported MS-based ide...

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Principais autores:	Aaron Wacholder, Eric W. Deutsch, Leron W. Kok, Jip T. van Dinter, Jiwon Lee, James C. Wright, Sebastien Leblanc, Ayodya H. Jayatissa, Kevin Jiang, Ihor Arefiev, Kevin Cao, Francis Bourassa, Felix-Antoine Trifiro, Michal Bassani-Sternberg, Pavel V. Baranov, Annelies Bogaert, Sonia Chothani, Ivo Fierro-Monti, Daria Fijalkowska, Kris Gevaert, Norbert Hubner, Jonathan M. Mudge, Jorge Ruiz-Orera, Jana Schulz, Juan Antonio Vizcaíno, John R. Prensner, Marie A. Brunet, Thomas F. Martinez, Sarah A. Slavoff, Xavier Roucou, Jyoti S. Choudhary, Sebastiaan van Heesch, Robert L. Moritz, Anne-Ruxandra Carvunis
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2026-01-01
Serier:	Nature Communications
Online adgang:	https://doi.org/10.1038/s41467-025-68002-x
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