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Genotypic and phenotypic characteristics of CXCR4-using transmitted/founder HIV-1 envelope glycoproteins

ABSTRACT The characteristics of HIV-1 envelope glycoproteins (Env) that initiate infection remain incompletely understood. In the primary HIV infection (PHI) stage, Envs using CCR5 as entry coreceptor (R5-tropic Envs) are much more frequent than those using CXCR4, alone or in addition to CCR5 (X4 or...

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Hlavní autoři: Dorine Martres, Théo Montagné, Sandra Pani, Nicolas Jeanne, Marie Armani-Tourret, Mary Requena, Camille Vellas, Stéphanie Raymond, Valérie Lorin, Yohan Gallois, Bénédicte Puissant-Lubrano, Hugo Mouquet, Pierre Delobel, Jacques Izopet, Bernard Lagane
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2026-06-01
Edice:Journal of Virology
Témata:
CXCR4
broadly neutralizing antibodies
primary HIV infection
envelope glycoprotein
viral tropism
HIV transmission
On-line přístup:https://journals.asm.org/doi/10.1128/jvi.00067-26
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