Efficient secretory expression of type III recombinant human collagen with triple-helical structure in Komagataella phaffii

Abstract Recombinant human collagen (rhCol) holds broad potential in biomedical and industrial applications due to its high purity and low immunogenicity. However, large-scale production of structurally stable and functionally active rhCol remains challenging. A novel strategy integrating collagen s...

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Principais autores:	Yaqian Ma, Yang Li, Nan Wang, Chenxiao Han, Qisheng Liu, Liqin Sun, Zhuqing Ma, Hailing Zhang
Format:	Artigo
Jezik:	Inglês
Izdano:	Springer 2025-09-01
Serija:	Applied Microbiology and Biotechnology
Teme:	Recombinant human collagen Komagataella phaffii Triple helix Prolyl-4-hydroxylase Protein expression
Online dostop:	https://doi.org/10.1007/s00253-025-13566-3
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