Small molecule induced STING degradation facilitated by the HECT ligase HERC4

Abstract Stimulator of interferon genes (STING) is a central component of the cytosolic nucleic acids sensing pathway and as such master regulator of the type I interferon response. Due to its critical role in physiology and its’ involvement in a variety of diseases, STING has been a focus for drug...

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Autori principali:	Merve Mutlu, Isabel Schmidt, Andrew I. Morrison, Benedikt Goretzki, Felix Freuler, Damien Begue, Oliver Simic, Nicolas Pythoud, Erik Ahrne, Sandra Kapps, Susan Roest, Debora Bonenfant, Delphine Jeanpierre, Thi-Thanh-Thao Tran, Rob Maher, Shaojian An, Amandine Rietsch, Florian Nigsch, Andreas Hofmann, John Reece-Hoyes, Christian N. Parker, Danilo Guerini
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2024-05-01
Serie:	Nature Communications
Accesso online:	https://doi.org/10.1038/s41467-024-48922-w
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