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Inhibiting Polo-like kinase 1 causes growth reduction and apoptosis in pediatric acute lymphoblastic leukemia cells

This study investigated Polo-like kinase 1, a mitotic regulator often over-expressed in solid tumors and adult hematopoietic malignancies, as a potential new target in the treatment of pediatric acute lymphoblastic leukemia. Polo-like kinase 1 protein and Thr210 phosphorylation levels were higher in...

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Príomhchruthaitheoirí: Stefanie A. Hartsink-Segers, Carla Exalto, Matthew Allen, Daniel Williamson, Steven C. Clifford, Martin Horstmann, Huib N. Caron, Rob Pieters, Monique L. Den Boer
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Ferrata Storti Foundation 2013-10-01
Sraith:Haematologica
Rochtain ar líne:https://haematologica.org/article/view/6804
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