Common protein-altering variant in GFAP is associated with white matter lesions in the older Japanese population

Abstract The genetic architecture of white matter lesions (WMLs) in Asian populations has not been well-characterized. Here, we performed a genome-wide association study (GWAS) to identify loci associated with the WML volume. Brain MRI and DNA samples were collected from 9479 participants in the Jap...

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Bibliografische Detailangaben

Hauptverfasser:	Yoshihiko Furuta, Masato Akiyama, Naoki Hirabayashi, Takanori Honda, Mao Shibata, Tomoyuki Ohara, Jun Hata, Chikashi Terao, Yukihide Momozawa, Yasuko Tatewaki, Yasuyuki Taki, Shigeyuki Nakaji, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Jun-ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya, On behalf of the Japan Prospective Studies for Aging and Dementia (JPSC-AD) Study Group
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2024-11-01
Schriftenreihe:	npj Genomic Medicine
Online-Zugang:	https://doi.org/10.1038/s41525-024-00431-x
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