PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy

Abstract PPTC7 is a resident mitochondrial phosphatase essential for maintaining proper mitochondrial content and function. Newborn mice lacking Pptc7 exhibit aberrant mitochondrial protein phosphorylation, suffer from a range of metabolic defects, and fail to survive beyond one day after birth. Usi...

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Auteurs principaux:	Natalie M. Niemi, Lia R. Serrano, Laura K. Muehlbauer, Catherine E. Balnis, Lianjie Wei, Andrew J. Smith, Keri-Lyn Kozul, Merima Forny, Olivia M. Connor, Edrees H. Rashan, Evgenia Shishkova, Kathryn L. Schueler, Mark P. Keller, Alan D. Attie, Jonathan R. Friedman, Julia K. Pagan, Joshua J. Coon, David J. Pagliarini
Format:	Artigo
Langue:	Inglês
Publié:	Nature Portfolio 2023-10-01
Collection:	Nature Communications
Accès en ligne:	https://doi.org/10.1038/s41467-023-42069-w
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