Spatial transcriptomics analysis uncovers ER stress in MANF-deficient Purkinje cells underlying alcohol-induced cerebellar neurodegeneration in mice

Abstract Alcohol use disorders (AUD) is one of the most prevalent mental disorders in the United States affecting more than 10% of the adult population. Cerebellar atrophy and Purkinje cell (PC) degeneration are frequently observed in patients with AUD. Alcohol can cause endoplasmic reticulum (ER) s...

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Autors principals:	Wen Wen, Hui Li, Li-Chun Lin, Michael S. Chimenti, Henry L. Keen, Mariah R. Leidinger, Di Hu, Zuohui Zhang, Hong Lin, Jia Luo
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-12-01
Col·lecció:	Acta Neuropathologica Communications
Matèries:	Alcohol use disorder Cerebellar dysfunction Sex difference Spatial transcriptomics Unfolded protein response
Accés en línia:	https://doi.org/10.1186/s40478-025-02162-1
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