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Epigenetic reprogramming via EZH2 inhibition rescues fibroadipose pathogenesis in secondary lymphedema through activating PPARγ signaling

Background: Secondary lymphedema, a progressive disorder characterized by pathological fibroadipose tissue accumulation, is a common problem after cancer treatment and orthopedic surgery. It remains a therapeutic enigma due to its self-perpetuating fibrotic cascade and lack of disease-modifying ther...

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Principais autores: Ziyu Chen, Zhi Yao, Mengfan Wu, Yuluan Wu, Jianlin Zhang, Zhuangyao Liao, Junyu Qian, Jiewen Wei, Lili Song, Longbiao Yu, Jingjing Wen, Zhegang Zhou, Yihao Wei, Yuefeng Yao, Zetao Ma, Pei Liu, Shailesh Agarwal, Ye Li, Lixiang Xue, Deli Wang
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-11-01
Serier:Journal of Orthopaedic Translation
Fag:
Secondary lymphedema
EZH2
Fibroadipose tissue
PPARγ
AdMSCs
Online adgang:http://www.sciencedirect.com/science/article/pii/S2214031X25001445
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