Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase

The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold via linkers of variable lengths is described. The multivalent inhibition potencies for the tacrine clusters were investigated for the inhibition of acetylcholinesterase. Two of the tacrine...

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Autores principales:	Tereza Cristina Santos Evangelista, Óscar López, Sabrina Baptista Ferreira, José G. Fernández-Bolaños, Magne O. Sydnes, Emil Lindbäck
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis Group 2021-01-01
Colección:	Journal of Enzyme Inhibition and Medicinal Chemistry
Materias:	acetylcholinesterase cuaac multivalent interactions multivalent inhibition potency tacrine
Acceso en línea:	http://dx.doi.org/10.1080/14756366.2021.1954917
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