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The ISG15-Protease USP18 Is a Pleiotropic Enhancer of HIV-1 Replication

The innate immune response to viruses is formed in part by interferon (IFN)-induced restriction factors, including ISG15, p21, and SAMHD1. IFN production can be blocked by the ISG15-specific protease USP18. HIV-1 has evolved to circumvent host immune surveillance. This mechanism might involve USP18....

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Autori principali: Chaohui Lin, Edmund Osei Kuffour, Taolan Li, Christoph G. W. Gertzen, Jesko Kaiser, Tom Luedde, Renate König, Holger Gohlke, Carsten Münk
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2024-03-01
Serie:Viruses
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Accesso online:https://www.mdpi.com/1999-4915/16/4/485
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