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High specificity of engineered T cells with third generation CAR (CD28-4-1BB-CD3-ζ) based on biotin-bound monomeric streptavidin for potential tumor immunotherapy

IntroductionImmunotherapy has revolutionized cancer treatment, and Chimeric Antigen Receptor T cell therapy (CAR-T) is a groundbreaking approach. Traditional second-generation CAR-T therapies have achieved remarkable success in hematological malignancies, but there is still room for improvement, par...

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Principais autores: Jorge Gallego-Valle, Verónica Astrid Pérez-Fernández, Jesús Rosales-Magallares, Sergio Gil-Manso, María Castellá, Europa Azucena Gonzalez-Navarro, Rafael Correa-Rocha, Manel Juan, Marjorie Pion
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2024-09-01
coleção:Frontiers in Immunology
Assuntos:
engineered cells
immunosuppression
Treg
Chimeric Antigen Receptor
streptavidin-based CAR
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1448752/full
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