NEMO/NF-κB signaling functions as a double-edged sword in PanIN formation versus progression to pancreatic cancer

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is marked by a dismal survival rate, lacking effective therapeutics due to its aggressive growth, late-stage diagnosis, and chemotherapy resistance. Despite debates on NF-κB targeting for PDAC treatment, no successful approach has emerged....

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Miltiadis Tsesmelis, Ulrike F. G. Büttner, Melanie Gerstenlauer, Uta Manfras, Konstantinos Tsesmelis, Ziwei Du, Nadine Sperb, Stephanie Ellen Weissinger, Peter Möller, Thomas F. E. Barth, Harald J. Maier, Lap Kwan Chan, Thomas Wirth
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	BMC 2024-05-01
Цуврал:	Molecular Cancer
Нөхцлүүд:	PDAC PanINs NEMO NF-κB Senescence Cerulein
Онлайн хандалт:	https://doi.org/10.1186/s12943-024-01989-x
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!