Improved polygenic risk prediction for alzheimer’s disease and related dementias using deep learning: age and APOE-stratified analysis

Abstract Background Alzheimer’s disease and related dementias (ADRD) are complex, polygenic conditions with substantial public health impact. Accurate genetic risk prediction may enable earlier identification and stratification of individuals at elevated risk. Objective To evaluate the predictive pe...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Shayan Mostafaei, Daniel Wikström Shemer, Jonathan K. L. Mak, Ida K. Karlsson, Sara Hägg
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-03-01
Colecção:	Alzheimer’s Research & Therapy
Assuntos:	Dementia Alzheimer Disease Polygenic Risk Scores Apolipoprotein E (APOE) Deep learning UK Biobank
Acesso em linha:	https://doi.org/10.1186/s13195-026-02011-w
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!