β-Hydroxybutyrate ameliorates lipopolysaccharide-induced liver injury through β-hydroxybutyrylation of the SOD2 protein in mice

Septic liver injury is a major complication of sepsis, driven in part by oxidative stress–induced macrophage inflammasome activation and hepatocyte apoptosis. β-Hydroxybutyrate (β-OHB), a key ketone body, induces lysine β-hydroxybutyrylation (Kbhb), a novel post-translational modification, yet its r...

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Hlavní autoři:	Ya-Ping Bai, Yan Zhang, Zhi-Yuan Chen, Kai Li, De-Guo Wang, Shu-Jun Wan, Cui-Wei Zhang, Yue Sun, Zhi-Chao Li, Kun Lv, Lei Zha, Xiang Kong
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2025-12-01
Edice:	Redox Biology
Témata:	β-Hydroxybutyrate (β-OHB) Lysine β-hydroxybutyrylation (kbhb) Superoxide dismutase 2 (SOD2) NLRP3 inflammasome Apoptosis
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2213231725004628
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