Exploring the disconnect: mechanisms underpinning the absence of physical function improvement with SGLT2 inhibitors

Current evidence suggests sodium-glucose cotransporter 2 inhibitors (SGLT2i) do not consistently improve patient physical function, despite improvements in clinical symptoms and reductions in both adiposity and body weight. We highlight heterogenous methodologies in SGLT2i physical function trials....

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Detalhes bibliográficos

Principais autores:	Cian Sutcliffe, Jack A. Sargeant, Thomas Yates, Melanie J. Davies, Luke A. Baker
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-05-01
coleção:	Frontiers in Systems Biology
Assuntos:	SGLT2 (sodium-glucose cotransporter 2) inhibitor Glucagon-like peptide 1 (GLP-1) receptor agonist physical function skeletal muscle glucose lowering medication mobility and ageing
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fsysb.2025.1593229/full
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