Structural determinants of monohydroxylated bile acids to activate β1 subunit-containing BK channels*s⃞

Lithocholate (LC) (10–300 μM) in physiological solution is sensed by vascular myocyte large conductance, calcium- and voltage-gated potassium (BK) channel β1 accessory subunits, leading to channel activation and arterial dilation. However, the structural features in steroid and target that determine...

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Autori principali:	Anna N. Bukiya, Jacob McMillan, Abby L. Parrill, Alejandro M. Dopico
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2008-11-01
Serie:	Journal of Lipid Research
Soggetti:	steroids protein-ligand interaction computational modeling maxiK channel vascular smooth muscle vasodilation
Accesso online:	http://www.sciencedirect.com/science/article/pii/S0022227520346216
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