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Adverse Drug Reactions of Olanzapine, Clozapine and Loxapine in Children and Youth: A Systematic Pharmacogenetic Review

Children and youth treated with antipsychotic drugs (APs) are particularly vulnerable to adverse drug reactions (ADRs) and prone to poor treatment response. In particular, interindividual variations in drug exposure can result from differential metabolism of APs by cytochromes, subject to genetic po...

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Principais autores: Diane Merino, Arnaud Fernandez, Alexandre O. Gérard, Nouha Ben Othman, Fanny Rocher, Florence Askenazy, Céline Verstuyft, Milou-Daniel Drici, Susanne Thümmler
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2022-06-01
Series:Pharmaceuticals
Assuntos:
cytochromes
<i>CYP1A2</i>
adverse drug reaction
antipsychotics
olanzapine
clozapine
Acceso en liña:https://www.mdpi.com/1424-8247/15/6/749
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