Zinc protoporphyrin binding to telomerase complexes and inhibition of telomerase activity*

Abstract Zinc protoporphyrin (ZnPP), a naturally occurring metalloprotoporphyrin (MPP), is currently under development as a chemotherapeutic agent although its mechanism is unclear. When tested against other MPPs, ZnPP was the most effective DNA synthesis and cellular proliferation inhibitor while p...

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Hlavní autoři:	Zhaowen Zhu, Huy Tran, Meleah M. Mathahs, Brian D. Fink, John A. Albert, Thomas O. Moninger, Jeffery L. Meier, Ming Li, Warren N. Schmidt
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2021-12-01
Edice:	Pharmacology Research & Perspectives
Témata:	cancer chemotherapy telomerase enzymatic activity telomerase reverse transcriptase telomere zinc protoporphyrin
On-line přístup:	https://doi.org/10.1002/prp2.882
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