A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation

Abstract Background Kv1.3 potassium channels regulate microglial functions and are overexpressed in neuroinflammatory diseases. Kv1.3 blockade may selectively inhibit pro-inflammatory microglia in neurological diseases but the molecular and cellular mechanisms regulated by Kv1.3 channels are poorly...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Srikant Rangaraju, Syed Ali Raza, Andrea Pennati, Qiudong Deng, Eric B. Dammer, Duc Duong, Michael W. Pennington, Malu G. Tansey, James J. Lah, Ranjita Betarbet, Nicholas T. Seyfried, Allan I. Levey
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2017-06-01
Schriftenreihe:	Journal of Neuroinflammation
Schlagworte:	Microglia Neuroinflammation Potassium channels Kv1.3 Proteomics
Online-Zugang:	http://link.springer.com/article/10.1186/s12974-017-0906-6
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