Spatial immune profiling complements genomic sequencing in biliary tract cancer: hypothesis-generating use cases

Background: Personalized therapy approaches targeting homologous recombination deficiency (HRD) in biliary tract cancer (BTC) remain poorly explored with limited clinical data available. Beyond BRCA1/2, the therapeutic implications of BRCA1-associated protein 1 (BAP1) alterations are unclear. Materi...

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Autores principales:	M. Barsch, I. Godbole, P. Metzger, M. Benzing, L. Klaas, A. Decker, A. Dammer, J. Weiß, E.-P. Dopfer, L. Gräßel, J. Kuehn, C. Miething, H. Becker, S. Lassmann, P. Bronsert, A.M. Schultheis, M. Werner, M. Boerries, J. Duyster, R. Thimme, M. Hofmann, M. Quante, B. Bengsch
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2026-06-01
Colección:	ESMO Gastrointestinal Oncology
Materias:	biliary tract cancer precision oncology molecular tumor board imaging mass cytometry tumor immune microenvironment BAP1
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S294981982600018X
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