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Effects of thrombomodulin alfa on hemostatic parameters in disseminated intravascular coagulation: Post hoc analysis of a phase 3 randomized controlled trial

Abstract Background The efficacy and safety of thrombomodulin alfa (TM‐α), a cofactor protein promoting thrombin‐mediated protein C activation, have been examined in a phase 3 randomized, double‐blinded, parallel‐group trial in Japan. We have previously reported that TM‐α is noninferior to heparin f...

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Principais autores: Takashi Ito, Ikuro Maruyama, Shuji Shimazaki, Yasuhiro Yamamoto, Naoki Aikawa, Akio Hirayama, Goichi Honda, Hidehiko Saito
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020-10-01
Serier:Research and Practice in Thrombosis and Haemostasis
Fag:
disseminated intravascular coagulation
heparin
protein C
thrombin
thrombomodulin
Online adgang:https://doi.org/10.1002/rth2.12419
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