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Donor-dependent heterogeneity in therapeutic effects of adipose tissue extracellular vesicles

Abstract Background Extracellular vesicles (EVs) are promising therapeutics for diseases associated with inflammation and tissue remodeling. However, a major limitation for the clinical translation of EV therapeutics is heterogeneity, which is donor dependent. In this study we sought to assess the p...

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Principais autores: Danielle J. Beetler, Presley Giresi, Vivian Xu, Elizabeth J. McCabe, Jessica J. Fliess, Alayna M. Puls, Matthew E. Auda, Molly M. Watkins, Sierra A. Walker, Damian N. Di Florio, Dalila Iannotta, Emily R. Whelan, Logan P. Macomb, Kevin C. Keegan, Angita Jain, Varsini Balamurugan, Sami Khatib, Gabriel J. Weigel, David J. Gorelov, Anthony Pham, Brandy H. Edenfield, Leslie T. Cooper, Houssam Farres, Shane A. Shapiro, Katelyn A. Bruno, Joy Wolfram, DeLisa Fairweather
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2025-11-01
coleção:Cell Communication and Signaling
Assuntos:
Anti-inflammatory
Exosomes
Lipoaspirate
Microvesicles
Myocarditis
Tangential flow filtration
Acesso em linha:https://doi.org/10.1186/s12964-025-02563-8
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