Dock4 is required for the maintenance of cochlear hair cells and hearing function

Auditory hair cells (HCs) are the mechanosensory receptors of the cochlea, and HC loss or malfunction can result from genetic defects. Dock4, a member of the Dock180-related protein superfamily, is a guanine nucleotide exchange factor for Rac1, and previous reports have shown that Dock4 mutations ar...

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Autores principales:	Guodong Hong, Xiaolong Fu, Jieyu Qi, Buwei Shao, Xuan Han, Yuan Fang, Shuang Liu, Cheng Cheng, Chengwen Zhu, Junyan Gao, Xia Gao, Jie Chen, Ming Xia, Wei Xiong, Renjie Chai
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	KeAi Communications Co. Ltd. 2023-07-01
Colección:	Fundamental Research
Materias:	Hair cell Stereocilia Oxidative stress Apoptosis Hearing loss Dock4
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S2667325822001996
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