LC-UV Determination of Baicalin in Rabbit Plasma and Tissues for Application in Pharmacokinetics and Tissue Distribution Studies of Baicalin after Intravenous Administration of Liposomal and Injectable Formulations

A simple and sensitive LC-UV method to investigate the pharmacokinetics and biodistribution pattern of baicalin in rabbits was established and validated. Baicalin and the internal standard, rutin, were extracted from biosamples using acetonitrile as protein precipitation after pretreated with ammoni...

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主要な著者:	Yumeng Wei, Chao Pi, Gang Yang, Xiaoming Xiong, Yongshu Lan, Hongru Yang, Yang Zhou, Yun Ye, Yonggen Zou, Wenwu Zheng, Ling Zhao
フォーマット:	Artigo
言語:	Inglês
出版事項:	MDPI AG 2016-04-01
シリーズ:	Molecules
主題:	pharmacokinetics tissue distribution LC-UV lung targeting baicalin
オンライン･アクセス:	http://www.mdpi.com/1420-3049/21/4/444
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