Cerebral organoids expressing mutant actin genes reveal cellular mechanism underlying microcephaly

Abstract Actins are cytoskeletal proteins that are essential for multiple cellular processes. Mutations in the ACTB and ACTG1 genes, encoding the ubiquitous beta- and gamma-cytoskeletal actin isoforms, respectively, cause a broad spectrum of neurodevelopmental disorders, with microcephaly as the mos...

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Библиографические подробности

Главные авторы:	Indra Niehaus, Michaela Wilsch-Bräuninger, Felipe Mora-Bermúdez, Fabian Rost, Mihaela Bobic-Rasonja, Velena Radosevic, Marija Milkovic-Perisa, Pauline Wimberger, Mariasavina Severino, Alexandra Haase, Ulrich Martin, Karolina Kuenzel, Kaomei Guan, Katrin Neumann, Noreen Walker, Evelin Schröck, Natasa Jovanov-Milosevic, Wieland B Huttner, Nataliya Di Donato, Michael Heide
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Springer Nature 2025-12-01
Серии:	EMBO Reports
Предметы:	Cerebral Organoids Actin Disease Modeling Mitotic Spindle Microcephaly
Online-ссылка:	https://doi.org/10.1038/s44319-025-00647-7
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