QR Code

Human cytomegalovirus IE1 protein alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome

Human cytomegalovirus (hCMV) immediate early 1 (IE1) protein associates with condensed chromatin of the host cell during mitosis. We have determined the structure of the chromatin-tethering domain (CTD) of IE1 bound to the nucleosome core particle, and discovered that the specific interaction betwee...

Full description

Saved in:
Main Authors: Qianglin Fang, Ping Chen, Mingzhu Wang, Junnan Fang, Na Yang, Guohong Li, Rui-Ming Xu
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications Ltd 2016-01-01
Series:eLife
Subjects:
nucleosome
cytomegalovirus
crystal structure
chromatin
Online Access:https://elifesciences.org/articles/11911
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items