Immunotherapeutic potential of PD-1 blockade in chronic Leishmania mexicana infection through the enhancement of progenitor-like CXCR5+ and intermediate CXCR5+TIM-3+ exhausted T cells

Diffuse cutaneous leishmaniasis (DCL), caused by Leishmania mexicana, is a chronic, treatment-refractory form of leishmaniasis characterized by multiple nodular lesions and high parasite load. During chronic infection, T cells acquire an exhausted immune state marked by elevated expression of PD-1 a...

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Principais autores:	Mariana Diupotex, Julián A. Gajón, Laura C. Bonifaz, Jaime Zamora-Chimal, Ingeborg Becker
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-06-01
coleção:	Frontiers in Immunology
Assuntos:	anti-PD-1 chronic infection cutaneous leishmaniasis immunotherapy progenitor-like T cells T-cell exhaustion
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1827753/full
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