Aire Disruption Influences the Medullary Thymic Epithelial Cell Transcriptome and Interaction With Thymocytes

The function of medullary thymic epithelial cells (mTECs) is associated with thymocyte adhesion, which is crucial for the negative selection of autoreactive thymocytes in the thymus. This process represents the root of central tolerance of self-components and prevents the onset of autoimmune disease...

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Detalhes bibliográficos

Principais autores:	Cesar A. Speck-Hernandez, Amanda F. Assis, Rafaela F. Felicio, Larissa Cotrim-Sousa, Nicole Pezzi, Gabriel S. Lopes, Karina F. Bombonato-Prado, Silvana Giuliatti, Geraldo A. Passos
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2018-05-01
coleção:	Frontiers in Immunology
Assuntos:	Aire gene cell adhesion transcriptome medullary thymic epithelial cells immune tolerance
Acesso em linha:	http://journal.frontiersin.org/article/10.3389/fimmu.2018.00964/full
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