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Allosteric mechanism of signal transduction in the two-component system histidine kinase PhoQ

Transmembrane signaling proteins couple extracytosolic sensors to cytosolic effectors. Here, we examine how binding of Mg2+ to the sensor domain of an E. coli two component histidine kinase (HK), PhoQ, modulates its cytoplasmic kinase domain. We use cysteine-crosslinking and reporter-gene assays to...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Bruk Mensa, Nicholas F Polizzi, Kathleen S Molnar, Andrew M Natale, Thomas Lemmin, William F DeGrado
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications Ltd 2021-12-01
Saila:eLife
Gaiak:
Sarrera elektronikoa:https://elifesciences.org/articles/73336
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