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Epigenetic silencing of SALL3 is an independent predictor of poor survival in head and neck cancer

Abstract Background This study examined Sal-like protein (SALL)3 methylation profiles of head and neck cancer (HNSCC) patients at diagnosis and follow-up and evaluated their prognostic significance and value as a biomarker. SALL3 expression was examined in a panel of cell lines by quantitative rever...

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Main Authors: Kiyoshi Misawa, Daiki Mochizuki, Atsushi Imai, Yuki Misawa, Shiori Endo, Masato Mima, Hideya Kawasaki, Thomas E. Carey, Takeharu Kanazawa
Format: Artigo
Language:Inglês
Published: BMC 2017-06-01
Series:Clinical Epigenetics
Subjects:
SALL3
Hypermethylation
Tumor-suppressor genes
Head and neck cancer
Biomarker
Real-time PCR
Online Access:http://link.springer.com/article/10.1186/s13148-017-0363-1
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