Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation

<p>Abstract</p> <p>Background</p> <p>T cell activation is associated with a rapid increase in intracellular fructose-2,6-bisphosphate (F2,6BP), an allosteric activator of the glycolytic enzyme, 6-phosphofructo-1-kinase. The steady state concentration of F2,6BP in T cells is dependent on the expressi...

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Detalhes bibliográficos

Principais autores:	Telang Sucheta, Clem Brian F, Klarer Alden C, Clem Amy L, Trent John O, Bucala Richard, Chesney Jason
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2012-05-01
coleção:	Journal of Translational Medicine
Assuntos:	Glycolysis 6-Phosphofructo-2-kinase/fructose-2, 6-bisphosphatase Fructose-2 6-bisphosphate T cell
Acesso em linha:	http://www.translational-medicine.com/content/10/1/95
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