Molecular mechanisms and consequences of TDP-43 phosphorylation in neurodegeneration

Abstract Increased phosphorylation of TDP-43 is a pathological hallmark of several neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, the regulation and roles of TDP-43 phosphorylation remain incompletely understood. A variety of te...

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Bibliografische gegevens

Hoofdauteurs:	Elise A. Kellett, Adekunle T. Bademosi, Adam K. Walker
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	BMC 2025-05-01
Reeks:	Molecular Neurodegeneration
Onderwerpen:	TDP-43 Phosphorylation Amyotrophic lateral sclerosis Frontotemporal dementia Post-translational modifications Neurodegeneration
Online toegang:	https://doi.org/10.1186/s13024-025-00839-8
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