The yin–yang of kinase activation and unfolding explains the peculiarity of Val600 in the activation segment of BRAF

Many driver mutations in cancer are specific in that they occur at significantly higher rates than – presumably – functionally alternative mutations. For example, V600E in the BRAF hydrophobic activation segment (AS) pocket accounts for >95% of all kinase mutations. While many hypotheses tried to...

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Détails bibliographiques

Auteurs principaux:	Christina Kiel, Hannah Benisty, Veronica Lloréns-Rico, Luis Serrano
Format:	Artigo
Langue:	Inglês
Publié:	eLife Sciences Publications Ltd 2016-01-01
Collection:	eLife
Sujets:	structure-energy calculations genotype-phenotype association passenger and driver mutations
Accès en ligne:	https://elifesciences.org/articles/12814
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