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CagY-Dependent Regulation of Type IV Secretion in <named-content content-type="genus-species">Helicobacter pylori</named-content> Is Associated with Alterations in Integrin Binding

ABSTRACT Strains of Helicobacter pylori that cause ulcer or gastric cancer typically express a type IV secretion system (T4SS) encoded by the cag pathogenicity island (cagPAI). CagY is an ortholog of VirB10 that, unlike other VirB10 orthologs, has a large middle repeat region (MRR) with extensive re...

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Principais autores: Emma C. Skoog, Vasilios A. Morikis, Miriam E. Martin, Greg A. Foster, Lucy P. Cai, Lori M. Hansen, Beibei Li, Jennifer A. Gaddy, Scott I. Simon, Jay V. Solnick
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018-07-01
coleção:mBio
Assuntos:
CagA
CagY
Helicobacter pylori
integrin
pathogenicity island
type IV secretion system
Acesso em linha:https://journals.asm.org/doi/10.1128/mBio.00717-18
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