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GPR84 potently inhibits osteoclastogenesis and alleviates osteolysis in bone metastasis of colorectal cancer

Abstract The expression of GPR84 in bone marrow-derived monocytes/macrophages (BMMs) can inhibit osteoclast formation; however, its role in bone metastasis of colorectal cancer (CRC) is still unknown. To investigate the effects of GPR84 on bone metastasis of CRC, the murine CRC cell line MC-38 was i...

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Principais autores: Li Jian, Long Shi-wei, Jing Dan, Wu Juan, Zheng Wei
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2023-01-01
Serier:Journal of Orthopaedic Surgery and Research
Fag:
GPR84
BMMs
MAPK pathway
Bone metastasis
Colorectal cancer
Online adgang:https://doi.org/10.1186/s13018-022-03473-y
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