Downregulation of Cathepsin B expression alleviates periodontitis by reducing mitochondrial reactive oxygen species production and NOD-, LRR-, and pyrin domain-containing 3 -mediated pyroptosis

BackgroundPeriodontitis is one of the most common oral inflammatory diseases, and NOD-, LRR-, and pyrin domain-containing 3 (NLRP3)-mediated pyroptosis plays a crucial role in its pathogenesis. Cathepsin B (CTSB), a lysosomal cysteine protease, is closely associated with programmed cell death. Our s...

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Detalhes bibliográficos

Principais autores:	Tianqi Wang, Xinran Liu, Jiaxin Li, Yan Ding, Yuan Yue, Jinle Li, Min Wang, Na Wei, Liang Hao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-03-01
Colecção:	Frontiers in Immunology
Assuntos:	periodontitis pyroptosis Cathepsin B NOD LRR domain-containing 3
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1762290/full
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