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The Prevention of Developmental Delay and Xylitol (PDDaX) trial: study protocol of a nested cohort follow-up from the PPaX (Prevention of Prematurity and Xylitol) trial examining neurodevelopmental outcomes among offspring at 4–8 years of age in Malawi

Abstract Background We recently conducted the cluster-randomized, Prevention of Prematurity and Xylitol (PPaX) trial which demonstrated a significant reduction in the occurrence of delivery of preterm and low birthweight deliveries from mothers who used twice-daily xylitol-containing chewing gum in...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Gregory C. Valentine, Brent Collett, Shaphil Wallie, Joseph Mhango, Cyril Engmann, Erin Sullivan, Maxim Seferovic, Michael Willoughby, Benjamin Shayo, Judd L. Walson, Peter Milgrom, Kjersti Aagaard, Sandra E. Juul
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2025-11-01
Schriftenreihe:Trials
Schlagworte:
Neurodevelopment
Xylitol
Prematurity
Global health
Development
Inflammation
Online-Zugang:https://doi.org/10.1186/s13063-025-09204-y
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