Improved efficacy against malignant brain tumors with EGFRwt/EGFRvIII targeting immunotoxin and checkpoint inhibitor combinations

Abstract Background D2C7-IT is a novel immunotoxin (IT) targeting wild-type epidermal growth factor receptor (EGFRwt) and mutant EGFR variant III (EGFRvIII) proteins in glioblastoma. In addition to inherent tumoricidal activity, immunotoxins induce secondary immune responses through the activation o...

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Detalhes bibliográficos

Principais autores:	Vidyalakshmi Chandramohan, Xuhui Bao, Xin Yu, Scott Parker, Charlotte McDowall, Yen-Rei Yu, Patrick Healy, Annick Desjardins, Michael D. Gunn, Matthias Gromeier, Smita K. Nair, Ira H. Pastan, Darell D. Bigner
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMJ Publishing Group 2019-05-01
Colecção:	Journal for ImmunoTherapy of Cancer
Assuntos:	Immunotoxin Immune checkpoint inhibitors EGFR T cells Malignant gliomas
Acesso em linha:	http://link.springer.com/article/10.1186/s40425-019-0614-0
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