A phenome-wide hunt for risk factors of Alzheimer’s disease: from metabolic clues to neuroimaging evidence

Abstract Background This study systematically investigated phenotypes causally associated with Alzheimer’s disease (AD) across the phenome and validated the findings at cognitive and neuroimaging levels using real-world clinical data. Methods We performed phenome-wide Mendelian Randomization (MR) an...

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Detalhes bibliográficos

Principais autores:	Dongming Liu, Ancha Baranova, Wenxi Sun, Hongbao Cao, Bing Zhang, Fuquan Zhang, for the Alzheimer’s Disease Neuroimaging Initiative, for the Alzheimer’s Disease Metabolomics Consortium
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-02-01
coleção:	Journal of Translational Medicine
Assuntos:	Alzheimer’s disease Mendelian randomization Metabolic syndrome Low-density lipoprotein Hippocampus
Acesso em linha:	https://doi.org/10.1186/s12967-026-07756-4
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