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<i>Prg4</i> and Osteoarthritis: Functions, Regulatory Factors, and Treatment Strategies

Proteoglycan 4 (PRG4), also known as lubricin, plays a critical role in maintaining joint homeostasis by reducing friction between articular cartilage surfaces and preventing cartilage degradation. Its deficiency leads to early-onset osteoarthritis (OA), while overexpression can protect against cart...

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Hoofdauteurs: Peng-Jie Fu, Sheng-Yuan Zheng, Yan Luo, Zhuo-Qun Ren, Zi-Han Li, Ya-Ping Wang, Bang-Bao Lu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI AG 2025-03-01
Reeks:Biomedicines
Onderwerpen:
Prg4
osteoarthritis
lubricin
TGF-β
transcription factor
Wnt
Online toegang:https://www.mdpi.com/2227-9059/13/3/693
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