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Nucleoporin107 mediates female sexual differentiation via Dsx

We recently identified a missense mutation in Nucleoporin107 (Nup107; D447N) underlying XX-ovarian-dysgenesis, a rare disorder characterized by underdeveloped and dysfunctional ovaries. Modeling of the human mutation in Drosophila or specific knockdown of Nup107 in the gonadal soma resulted in ovari...

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Uloženo v:
Hlavní autoři: Tikva Shore, Tgst Levi, Rachel Kalifa, Amatzia Dreifuss, Dina Rekler, Ariella Weinberg-Shukron, Yuval Nevo, Tzofia Bialistoky, Victoria Moyal, Merav Yaffa Gold, Shira Leebhoff, David Zangen, Girish Deshpande, Offer Gerlitz
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications Ltd 2022-03-01
Edice:eLife
Témata:
Nucleoporin107
sex differentiation
ovarian development
Dpp pathway
On-line přístup:https://elifesciences.org/articles/72632
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