Intra-channel bi-epitopic crosslinking unleashes ultrapotent antibodies targeting NaV1.7 for pain alleviation

Summary: Crucial for cell activities, ion channels are key drug discovery targets. Although small-molecule and peptide modulators dominate ion channel drug discovery, antibodies are emerging as an alternative modality. However, challenges persist in generating potent antibodies, especially for chann...

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Autors principals:	Yaning Zhang, Yanchao Ding, Ziyan Zeng, Rui Zhu, Peiyuan Zheng, Shilong Fan, Qingjuan Cao, Hang Chen, Weishuai Ren, Mengling Wu, Luyao Wang, Juanjuan Du
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2024-11-01
Col·lecció:	Cell Reports Medicine
Matèries:	bispecific antibody biparatopic antibody ion channel pain NaV1.7 avidity
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2666379124005470
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