Dihydroceramide desaturase promotes the formation of intraluminal vesicles and inhibits autophagy to increase exosome production

Summary: Exosomes are important for cell–cell communication. Deficiencies in the human dihydroceramide desaturase gene, DEGS1, increase the dihydroceramide-to-ceramide ratio and cause hypomyelinating leukodystrophy. However, the disease mechanism remains unknown. Here, we developed an in vivo assay...

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Detalhes bibliográficos

Principais autores:	Chen-Yi Wu, Jhih-Gang Jhang, Wan-Syuan Lin, Pei-Huan Chuang, Chih-Wei Lin, Li-An Chu, Ann-Shyn Chiang, Han-Chen Ho, Chih-Chiang Chan, Shu-Yi Huang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2021-12-01
coleção:	iScience
Assuntos:	Cell biology Functional aspects of cell biology
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2589004221014085
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