Combined angiotensin-converting enzyme and aminopeptidase inhibition for treatment of experimental ventilator-induced lung injury in mice

Introduction: Ventilator-induced lung injury (VILI) may aggravate critical illness. Although angiotensin-converting enzyme (ACE) inhibition has beneficial effects in ventilator-induced lung injury, its clinical application is impeded by concomitant hypotension. We hypothesized that the aminopeptidas...

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Hlavní autoři:	Xinjun Mao, Verena Tretter, Yi Zhu, Felix Kraft, Benjamin Vigl, Marko Poglitsch, Roman Ullrich, Dietmar Abraham, Katharina Krenn
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2023-03-01
Edice:	Frontiers in Physiology
Témata:	ventilator-induced lung injury renin-angiotensin system aminopeptidase angiotensin-converting enzyme inhibitor hypotension
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fphys.2023.1109452/full
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