Bithionol is ineffective in a mouse model of S. aureus implant-associated osteomyelitis despite potent in vitro activity

Abstract Implant-associated osteomyelitis (IAOM) is a severe complication of the usage of orthopaedic implants. IAOM is difficult to treat and infection relapse is often due to insufficient treatment of bacterial persister cells. The anthelmintic drug bithionol is promising in combating persister ce...

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Autors principals:	Anders Marthinsen Seefeldt, Mikkel Illemann Johansen, Freja Winther Sillesen, Maiken Engelbrecht Petersen, Lars Østergaard, Rikke Louise Meyer, Nis Pedersen Jørgensen
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-07-01
Col·lecció:	Scientific Reports
Accés en línia:	https://doi.org/10.1038/s41598-025-08879-2
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